par Verniory, André 
;Du Bois, R.;Decoodt, Pierre
Référence The Journal of general physiology, 62, 4, page (489-507)
Publication Publié, 1973
;Du Bois, R.;Decoodt, Pierre Référence The Journal of general physiology, 62, 4, page (489-507)
Publication Publié, 1973
Article révisé par les pairs
| Résumé : | The transport equation describing the flow of solute across a membrane has been modified on the basis of theoretical studies calculating the drag of a sphere moving in a viscous liquid undergoing Poiseuille flow inside a cylinder. It is shown that different frictional resistance terms should be introduced to calculate the contributions of diffusion and convection. New sieving equations are derived to calculate γ and Ap/Δx (respectively, the pore radius and the total area of the pores per unit of path length). These equations provide a better agreement than the older formulas between the calculated and the experimental glomerular sieving coefficents for [ 125I] polyvinyl pyrrolidone (PVP) fractions with a mean equivalent radius between 9 and 37 Å. From γ and Ap/Δx, the mean effective glomerular filtration pressure has been calculated, applying Poiseuille's law. A value of 5.4 mm Hg has been derived from the mean sieving curve obtained from 23 experiments performed on normal anesthetized dogs. |
