Titre:
  • Phase i study of lonafarnib (SCH66336) in combination with trastuzumab plus paclitaxel in Her2/neu overexpressing breast cancer: EORTC study 16023
Auteur:Kerklaan, Bojana Milojkovic; Diéras, Véronique; Le Tourneau, Christophe; Mergui-Roelvink, Marja; Huitema, Alwin Dr; Rosing, Hilde; Beijnen, Jos J.H.; Marreaud, Sandrine; Govaerts, Anne-Sophie; Piccart-Gebhart, Martine; Schellens, Jan J.H.M.; Awada, Ahmad
Informations sur la publication:Cancer chemotherapy and pharmacology, 71, 1, page (53-62)
Statut de publication:Publié, 2013-01
Sujet CREF:Cancérologie
Pharmacologie
Toxicologie pharmaceutique
Mots-clés:Activated MAPK pathway
Chemotherapy
Farnesyl transferase inhibitor
Her2-positive breast cancer
Lonafarnib
Paclitaxel
Trastuzumab
MeSH keywords:Adult
Aged
Antibodies, Monoclonal, Humanized -- administration & dosage
Antineoplastic Combined Chemotherapy Protocols -- adverse effects -- pharmacokinetics -- therapeutic use
Breast Neoplasms -- drug therapy -- genetics
Dose-Response Relationship, Drug
Female
Humans
Maximum Tolerated Dose
Middle Aged
Paclitaxel -- administration & dosage
Piperidines -- administration & dosage
Pyridines -- administration & dosage
Receptor, ErbB-2 -- genetics
Treatment Outcome
Note générale:SCOPUS: ar.j
Langue:Anglais
Identificateurs:urn:issn:0344-5704
info:doi/10.1007/s00280-012-1972-1
info:scp/84872279532
info:pmid/23053259