Titre:
  • 5-Substituted tetrazoles as bioisosteres of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials
Auteur:Biot, Christophe; Bauer, Holger G.; Schirmer, Rolf Heiner; Davioud-Charvet, Elisabeth
Informations sur la publication:Journal of medicinal chemistry, 47, 24, page (5972-5983)
Statut de publication:Publié, 2004-11
Sujet CREF:Biologie moléculaire
Pharmacologie
MeSH keywords:Animals
Antimalarials -- chemical synthesis -- chemistry -- pharmacology
Biological Availability
Caproates -- chemical synthesis -- chemistry -- pharmacology
Cell Line
Drug Resistance
Glutathione Reductase -- antagonists & inhibitors -- chemistry
Humans
Ligands
Models, Molecular
Molecular Structure
Naphthoquinones -- chemical synthesis -- chemistry -- pharmacology
Plasmodium falciparum -- drug effects
Prodrugs -- chemical synthesis -- chemistry -- pharmacology
Quantitative Structure-Activity Relationship
Tetrazoles -- chemical synthesis -- chemistry -- pharmacology
Note générale:SCOPUS: ar.j
Langue:Anglais
Identificateurs:urn:issn:0022-2623
info:doi/10.1021/jm0497545
info:scp/8644263983
info:pmid/15537352
VX-003074