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Synthèse des protéines et vitesse de renouvellement du phosphore de l'acide ribonucléique

par Grenson, Marcelle
Référence Biochimica et biophysica acta, 12, 1-2, page (560-569)
Publication Publié, 1953-10

Article révisé par les pairs

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Résumé :

A comparative study of the rate of protein sythesis and the rate of renewal of the RNA P in bird feather buds, laying hen's oviduct and mouse pancreas shows that, although these three organs synthesize proteins at a very high rate, the first tissue seems to present a parallel renewal of RNA P, whereas in the oviduct and the pancreas (even when, in the latter, synthesis is increased by pilocarpin injection) this rate is very low, considerably lower than the rate of protein synthesis. Thus, there does not exist a necessary relationship between the rate of renewal of RNA P and the rate of protein synthesis. These results are not in favour of the hypothesis which ascribes to RNA a metabolic role in protein synthesis, but, on the contrary, supports the idea that, if RNA does play a role in protein synthesis, as numerous experimental results seem to indicate, its action resembles more that of a model, a pattern or a catalytic agent. © 1953.