par Grandjean, Hélène;Larroque, Daniéle;Levi, Salvator
Référence Annals of the New York Academy of Sciences, 847, page (118-124)
Publication Publié, 1998
Article révisé par les pairs
Résumé : In this prospective study, we recorded details on 3685 fetuses with congenital structural abnormalities from an unselected population of women who underwent routine ultrasound examination during their pregnancies. Overall, 2262 fetuses were diagnosed as being abnormal before birth (sensitivity = 61.4%). The total number of abnormalities was 4615, of which 1733 (37.5%) were major abnormalities. The overall number of detected abnormalities was 2593 (sensitivity = 56.2%). If only major abnormalities were considered, the sensitivity rose to 73.7%, compared to only 45.7% for the minor abnormalities. Within each severity group, the accuracy of detection varied across systems. For the major abnormalities, it was higher for the central nervous system (88.3%) and urinary tract (84.8%), but lower for heart and great vessels (38.8%). Detection of minor abnormalities was also effective for the urinary tract (89.1%), but not for the heart and great vessels (20.8%) and the musculoskeletal system (18%).