par Lemonnier, Daniel;Winand, Jacques 
;Furnelle, Jacques ;Christophe, Jean
Référence Diabetologia, 7, 5, page (328-333)
Publication Publié, 1971-10
;Furnelle, Jacques ;Christophe, Jean Référence Diabetologia, 7, 5, page (328-333)
Publication Publié, 1971-10
Article révisé par les pairs
| Résumé : | Dietary obesity induced by a high-fat diet was superimposed in mice already suffering from the hereditary obese-hyperglycaemic (O-H) syndrome. Six-weekold animals given a diet containing 41.5% lard for 4.5 months gained 150% more weight than those given a control 78.3% wheat flour diet. There was only a slightly significant difference in weight gain of the lean littermates given the same two diets. - The interaction of the high-fat diet and the ob/ob genotype led to a further enlargement of adipose cells and an increased number of mast cells in epididymal fat. Diabetes was not aggravated in spite of a reduction in the levels of serum insulin, and in the insulin content of the pancreas. -The contribution of lipogenesis and dietary fat to the development of this obesity of mixed origin was estimated from an analysis of the fatty acid distribution in the diet, in three fat pads (epididymal, perirenal and subcutaneous), and in the liver. From the linoleate contents, it follows that fat depot in O-H mice on a high-fat diet was made up of 4 times more exogenous fatty acids than endogenous acids, but in spite of this, net lipogenesis was hardly affected. Therefore, obese-hyperglycaemic mice have a tremendous capacity to deposit and retain any kind of fat. The fatty acid spectrum also indicates that a large portion of the dietary supply of palmitate and stearate was converted into palmitoleate and oleate. © 1971 Springer-Verlag. |
