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Expression of B7-1 by highly metastatic mouse T lymphomas induces optimal natural killer cell-mediated cytotoxicity

par Geldhof, Anja;Raes, Geert;Bakkus, Marleen;Devos, Sophie ;Thielemans, Kris M.;De Baetselier, Patrick
Référence Cancer research, 55, 13, page (2730-2733)
Publication Publié, 1995

Article révisé par les pairs

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Résumé :

The interaction between B7-1 and CD28 provides costimulatory signals not only for T cells but also for natural killer (NK) cells. Highly metastatic mouse T lymphoma cells (BW-Li) can escape from NK cell-mediated killing by expressing H-2D(k) molecules that negatively regulate NK lytic activity. We have analyzed whether B7-1:CD28 overrules the MHC class I-mediated inactivation of NK cells by transfecting BW-Li with the gene coding for B7- 1. Expression of B7-1 rendered BW-Li cells sensitive toward NK cells. The experimental metastatic capacity of the B7-1 transfectants was drastically reduced in both syngeneic AKR and SCID mice but could be restored in SCID-bg mice. These results provide direct evidence that B7-1 expression leads to NK- mediated elimination of metastasizing, NK-resistant tumor cells.