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A multicenter cohort study of dose-dense temozolomide (21 of 28 days) for the treatment of recurrent anaplastic astrocytoma or oligoastrocytoma

par Neyns, Bart;Chaskis, Cristo;Joosens, Eric;Menten, Johan;D'Hondt, Lionel;Branle, Fabrice ;Sadones, Jan;Michotte, Alex
Référence Cancer investigation, 26, 3, page (269-277)
Publication Publié, 2008-03

Article révisé par les pairs

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Résumé :

Dose-dense temozolomide schedules deplete O6-methylguanine methyltransferase and may overcome chemoresistance. This multicenter cohort study enrolled 19 patients (15 anaplastic astrocytoma, 4 anaplastic oligoastrocytoma) who received temozolomide (100 mg/m2/day for 21 consecutive days every 28-day cycle) at first recurrence, either until disease progression or 12 cycles. Six-month progression-free survival was 56%, comparing favorably with historic controls treated with the standard 5-day temozolomide schedule. Median survival was 12.9 months (95% CI: 3.7, 22 months). Among 15 evaluable patients, 2 had a complete or partial response, and 10 had stable disease. Grade 3 and 4 lymphopenia occurred in 53% and 47% of patients, respectively. Copyright © Informa Healthcare USA, Inc.