PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic bata-cell apoptosis via regulation of the BH3-only protein Bim.

Santin Gomez, Izortze; Moore, Fabrice; Colli, Maikel Luis; Gurzov, Esteban Nicolas; Marselli, Lorella; Marchetti, Piero; Eizirik, Decio L.

doi:doi/10.2337/db11-0758

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PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic bata-cell apoptosis via regulation of the BH3-only protein Bim.

par Santin Gomez, Izortze

;Moore, Fabrice

;Colli, Maikel Luis

;Gurzov, Esteban Nicolas

;Marselli, Lorella ;Marchetti, Piero ;Eizirik, Decio L.

Référence Diabetes (New York, N.Y.), 60, 12, page (3279-3288)
Publication Publié, 2011

Article révisé par les pairs

Résumé :

Genome-wide association studies allowed the identification of several associations between specific loci and type 1 diabetes (T1D). However, the mechanisms by which most candidate genes predispose to T1D remain unclear. We presently evaluated the mechanisms by which PTPN2, a candidate gene for T1D, modulates β-cell apoptosis after exposure to type I and II interferons (IFNs), cytokines that contribute to β-cell loss in early T1D.

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