Titre:
  • PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic bata-cell apoptosis via regulation of the BH3-only protein Bim.
Auteur:Santin Gomez, Izortze; Moore, Fabrice; Colli, Maikel L; Gurzov, Esteban Nicolas; Marselli, Lorella; Marchetti, Piero; Eizirik, Decio L.
Informations sur la publication:Diabetes, 60, 12, page (3279-3288)
Statut de publication:Publié, 2011
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Aged
Animals
Apoptosis -- drug effects -- genetics
Apoptosis Regulatory Proteins -- genetics -- metabolism
Blotting, Western
Cell Survival -- drug effects -- genetics
Cells, Cultured
Diabetes Mellitus, Type 1 -- genetics -- metabolism
Fluorescent Antibody Technique
Humans
Insulin-Secreting Cells -- cytology -- metabolism
Interferon-alpha -- pharmacology
Interferon-beta -- pharmacology
Membrane Proteins -- genetics -- metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 2 -- genetics -- metabolism
Proto-Oncogene Proteins -- genetics -- metabolism
RNA Interference
Rats
STAT1 Transcription Factor -- genetics -- metabolism
Note générale:Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
Langue:Anglais
Identificateurs:urn:issn:0012-1797
info:doi/10.2337/db11-0758
info:pii/db11-0758
info:scp/82255185820
info:pmid/21984578
PMC3219938