Titre :
  • Cytokines tumor necrosis factor-alpha and interferon-gamma induce pancreatic beta-cell apoptosis through STAT1-mediated Bim protein activation.
Auteur : Barthson, Jenny ; Germano, Carla M ; Moore, Fabrice ; Maida, Adriano ; Drucker, Daniel J ; Marchetti, Piero ; Gysemans, Conny ; Mathieu, Chantal ; Nuñez, Gabriel ; Jurisicova, Andrea ; Eizirik, Decio L. ; Gurzov, Esteban Nicolas
Informations sur la publication : The Journal of biological chemistry, 286, 45, (page 39632-39643)
Statut de publication : Publié, 2011
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Adult
Aged
Animals
Antiviral Agents -- metabolism -- pharmacology
Apoptosis -- drug effects -- physiology
Apoptosis Regulatory Proteins -- genetics -- metabolism
Cells, Cultured
Female
Gene Expression Regulation -- drug effects -- physiology
Gene Silencing
Humans
Insulin-Secreting Cells -- metabolism
Interferon-gamma -- genetics -- metabolism -- pharmacology
Male
Membrane Proteins -- genetics -- metabolism
Mice
Mice, Knockout
Middle Aged
Neuropeptides -- genetics -- metabolism
Proto-Oncogene Proteins -- genetics -- metabolism
STAT1 Transcription Factor -- genetics -- metabolism
Tumor Necrosis Factor-alpha -- genetics -- metabolism -- pharmacology
Tumor Suppressor Protein p53 -- genetics -- metabolism
Note : Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
Langue :
  • Anglais
Identificateurs : urn:issn:0021-9258 
info:doi/10.1074/jbc.M111.253591
info:pii/M111.253591
info:pmid/21937453
info:pmcid/PMC3234786