Titre:
  • High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis.
Auteur:Stijlemans, Benoît; Caljon, Guy; Natesan, Senthil Kumar A; Saerens, Dirk; Conrath, Katja; Perez-Morga, David; Skepper, Jeremy N; Nikolaou, Alexandros; Brys, Lea; Pays, Etienne; Magez, Stefan; Field, Mark C; De Baetselier, Patrick; Muyldermans, Serge
Informations sur la publication:P L o S Pathogens, 7, 6, page (e1002072)
Statut de publication:Publié, 2011-06
Sujet CREF:Sciences exactes et naturelles
Sciences bio-médicales et agricoles
MeSH keywords:Amino Acid Sequence
Animals
Antibodies, Protozoan -- immunology -- pharmacology -- therapeutic use
Antibody Affinity
Cells, Cultured
Down-Regulation -- drug effects
Endocytosis -- drug effects
Humans
Mice
Mice, Inbred C57BL
Models, Biological
Models, Molecular
Molecular Sequence Data
Nanoparticles
Trypanocidal Agents -- pharmacology -- therapeutic use
Trypanosoma brucei brucei -- immunology -- metabolism -- physiology -- ultrastructure
Trypanosomiasis, African -- immunology -- metabolism -- therapy
Variant Surface Glycoproteins, Trypanosoma -- immunology
Note générale:Evaluation Studies
Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
Langue:Anglais
Identificateurs:urn:issn:1553-7366
info:doi/10.1371/journal.ppat.1002072
info:pii/10-PLPA-RA-4101
info:scp/79959851947
info:pmid/21698216
PMC3116811
info:ulb-repo/set/1#19865