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In vitro pharmacological and toxicological effects of norterpene peroxides isolated from the Red Sea sponge Diacarnus erythraeanus on normal and cancer cells.

par Lefranc, Florence ;Nuzzo, Genoveffa;Hamdy, Nehal Aly;Fakhr, Issa;Moreno Y Banuls, Laetitia ;Van Goietsenoven, Gwendoline ;Villani, Guido;Mathieu, Véronique ;van Soest, Rob;Kiss, Robert ;Ciavatta, Maria Letizia
Référence Journal of natural products, 76, 9, page (1541-1547)
Publication Publié, 2013-09

Article révisé par les pairs

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Résumé :

Eight cyclic peroxide norterpenoids, compounds 1-8, have been isolated and characterized from the Red Sea sponge Diacarnus erythraeanus, including two new norsesterterpene derivatives (3, 4). Among these metabolites, (-)-muqubilin A (5) (nine cell lines analyzed) and the new compounds 3 and 4 (seven cell lines analyzed) displayed mean IC₅₀ growth inhibitory concentrations in vitro of <10 μM, while the remaining compounds (1, 6-8) were inactive in these cancer cell lines. Compound 5 displayed no selectivity between normal and cancer cells in terms of in vitro growth inhibition. Quantitative video microscopy analysis carried out on (-)-muqubilin A-treated cells validated the data obtained by means of the MTT colorimetric assay, while flow cytometry analysis revealed ROS production but no induction of apoptosis in cancer cells.