Titre :
  • TP53 mutation-correlated genes predict the risk of tumor relapse and identify MPS1 as a potential therapeutic kinase in TP53-mutated breast cancers.
Auteur : Győrffy, Balázs ; Bottai, Giulia ; Lehmann-Che, Jacqueline ; Kéri, György ; Orfi, László ; Iwamoto, Takayuki ; Desmedt, Christine ; Bianchini, Giampaolo ; Turner, Nicholas C ; de Thé, Hugues ; Andre, Fabrice ; Sotiriou, Christos ; Hortobagyi, Gabriel N. ; Di Leo, Angelo ; Pusztai, Lajos ; Santarpia, Libero
Informations sur la publication : Molecular Oncology, 8, 3, (page 508-19)
Statut de publication : Publié, 2014-05
Sujet CREF : Cancérologie
Médecine pathologie humaine
Mots-clés : Breast cancer subtypes
Chemotherapy
MPS1 protein kinase
SP600125
TP53 mutation status
Tumor relapse
Mots-clés MeSH : Anthracenes -- pharmacology
Breast -- drug effects -- metabolism -- pathology
Breast Neoplasms -- diagnosis -- drug therapy -- genetics -- pathology
Cell Cycle Proteins -- antagonists & inhibitors -- genetics
Cell Line, Tumor
Cell Survival
Female
Genes, p53
Humans
Mutation
Neoplasm Recurrence, Local -- diagnosis -- drug therapy -- genetics -- pathology
Prognosis
Protein-Serine-Threonine Kinases -- antagonists & inhibitors -- genetics
Protein-Tyrosine Kinases -- antagonists & inhibitors -- genetics
Survival Analysis
Tumor Suppressor Protein p53 -- genetics
Note : JOURNAL ARTICLE
SCOPUS: ar.j
Langue :
  • Anglais
Identificateurs : urn:issn:1574-7891 
info:doi/10.1016/j.molonc.2013.12.018
info:pii/S1574-7891(13)00190-7
info:pmid/24462521