par Crimi, Ettore;Taccone, Fabio 
;Infante, Teresa;Scolletta, Sabino;Crudele, Valeria;Napoli, Claudio
Référence Journal of critical care, 27, 2, page (108-118)
Publication Publié, 2012-04
;Infante, Teresa;Scolletta, Sabino;Crudele, Valeria;Napoli, ClaudioRéférence Journal of critical care, 27, 2, page (108-118)
Publication Publié, 2012-04
Article révisé par les pairs
| Résumé : | The endothelium represents the largest functional organ in the human body playing an active role in vasoregulation, coagulation, inflammation, and microvascular permeability. Endothelium contributes to maintain vascular integrity, intravascular volume, and tissue oxygenation promoting inflammatory network response for local defense and repair. Acid-basis homeostasis is an important physiologic parameter that controls cell function, and changes in pH can influence vascular tone by regulating endothelium and vascular smooth muscle cells. This review presents a current perspective of the effects of intracellular acidosis on the function and the basic regulatory mechanisms of endothelial cells. |
