Titre :
  • Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice.
Auteur : Takiishi, Tatiana ; Korf, Hannelie ; Van Belle, Tom L ; Robert, Sofie ; Grieco, Fabio Arturo ; Caluwaerts, Silvia ; Galleri, Letizia ; Spagnuolo, Isabella ; Steidler, Lothar ; Van Huynegem, Karolien ; Demetter, Pieter ; Wasserfall, Clive ; Atkinson, Mark ; Dotta, Francesco ; Rottiers, Pieter ; Gysemans, Conny ; Mathieu, Chantal
Informations sur la publication : The Journal of clinical investigation, 122, 5, (page 1717-1725)
Statut de publication : Publié, 2012-05
Sujet CREF : Anatomopathologie
Mots-clés MeSH : Animals
Antigens, CD3 -- immunology
Autoantigens -- biosynthesis -- genetics
Cell Count
Cell Proliferation
Combined Modality Therapy
Diabetes Mellitus, Type 1 -- immunology -- therapy
Humans
Hypoglycemic Agents -- therapeutic use
Immune Tolerance
Immunologic Factors -- therapeutic use
Immunosuppression
Insulin -- metabolism
Insulin-Secreting Cells -- metabolism -- pathology
Interleukin-10 -- biosynthesis -- genetics -- secretion
Intestinal Mucosa
Lactococcus lactis -- genetics -- metabolism
Mice
Mice, Inbred C57BL
Mice, Inbred NOD
Proinsulin -- biosynthesis -- genetics -- secretion
T-Lymphocytes, Regulatory -- metabolism -- physiology
Note : Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: no.j
Langue :
  • Anglais
Identificateurs : urn:issn:0021-9738 
info:doi/10.1172/JCI60530
info:pii/60530
info:pmid/22484814
info:pmcid/PMC3336982