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Gastric exocrine and endocrine cell morphology under prolonged acid inhibition therapy: results of a 5-year follow-up in the LOTUS trial.

par Fiocca, R;Mastracci, L;Attwood, S E;Ell, C.;Galmiche, Jean-Paul;Hatlebakk, J;Bärthel, A;Långström, G;Lind, T;Lundell, L;Devière, Jacques
Référence Alimentary pharmacology & therapeutics, 36, 10, page (959-971)
Publication Publié, 2012-11

Article révisé par les pairs

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Résumé :

Sustained acid inhibition with PPI stimulates gastrin secretion, exerting a proliferative drive on enterochromaffin-like cells (ECL cells) of the oxyntic mucosa. It may also accelerate development of gastric gland atrophy in Helicobacter pylori-infected individuals.