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In antibody-positive first-degree relatives of patients with type 1 diabetes, HLA-A*24 and HLA-B*18, but not HLA-B*39, are predictors of impending diabetes with distinct HLA-DQ interactions.

par Mbunwe, E;Van der Auwera, B J;Weets, Ilse;Van Crombrugge, P;Crenier, Laurent ;Coeckelberghs, M;Seret, Nicole;Decochez, K;Vandemeulebroucke, Evy;Gillard, P;Keymeulen, B;Van Schravendijk, C.;Wenzlau, J M;Hutton, J C;Pipeleers, Daniel;Gorus, F K;Belgian Diabetes Registry,
Référence Diabetologia, 56, 9, page (1964-1970)
Publication Publié, 2013-09

Article révisé par les pairs

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Résumé :

Secondary type 1 diabetes prevention trials require selection of participants with impending diabetes. HLA-A and -B alleles have been reported to promote disease progression. We investigated whether typing for HLA-B*18 and -B*39 may complement screening for HLA-DQ8, -DQ2 and -A*24 and autoantibodies (Abs) against islet antigen-2 (IA-2) and zinc transporter 8 (ZnT8) for predicting rapid progression to hyperglycaemia.