5-aza-2'-deoxycytidine has minor effects on differentiation in human thyroid cancer cell lines, but modulates genes that are involved in adaptation in vitro.

Dom, Geneviève; Galdo, Vanessa Chico; Tarabichi, Maxime; Tomás, Gil; Hebrant, Aline; Andry, Guy; De Martelar, Viviane; Libert, Frédérick; Leteurtre, Emmanuelle; Dumont, Jacques Emile; Maenhaut, Carine; van Staveren, Wilma C G

doi:doi/10.1089/thy.2012.0388

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5-aza-2'-deoxycytidine has minor effects on differentiation in human thyroid cancer cell lines, but modulates genes that are involved in adaptation in vitro.

par Dom, Geneviève

;Galdo, Vanessa Chico ;Tarabichi, Maxime

;Tomás, Gil ;Hebrant, Aline

;Andry, Guy

;De Martelar, Viviane ;Libert, Frédérick

;Leteurtre, Emmanuelle ;Dumont, Jacques Emile

;Maenhaut, Carine

;van Staveren, Wilma C G
Référence Thyroid, 23, 3, page (317-328)
Publication Publié, 2013-03

Article révisé par les pairs

Résumé :

In thyroid cancer, the lack of response to specific treatment, for example, radioactive iodine, can be caused by a loss of differentiation characteristics of tumor cells. It is hypothesized that this loss is due to epigenetic modifications. Therefore, drugs releasing epigenetic repression have been proposed to reverse this silencing.

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