par Jouvin, Kevin;Veillard, Romain;Theunissen, Cédric ;Alayrac, Carole;Gaumont, Annie-Claude;Evano, Gwilherm
Référence Organic letters, 15, page (4592-4595)
Publication Publié, 2013
Référence Organic letters, 15, page (4592-4595)
Publication Publié, 2013
Article révisé par les pairs
Résumé : | An original and user-friendly synthesis of alkynylphosphine-boranes, useful building blocks in organic synthesis, based on an oxidative P-alkynylation reaction with readily available copper acetylides is reported. The ability of a secondary phosphine protected with a borane to undergo oxidative coupling without oxidation of the P-moiety is demonstrated for the first time. The reaction, which proceeds at room temperature, is applicable to the preparation of enantioenriched and structurally complex alkynylphosphine-boranes. |