par Malaisse, Willy ;Sener, Abdullah
Editeur scientifique Conn, P. Michael
Référence Sourcebook of models for biomedical research, Humana Press, Totowa, USA, page (651-656)
Publication Publié, 2008
Partie d'ouvrage collectif
Résumé : This review deals with animal models of diabetes mellitus. Experimentally induced diabetes, such as that caused by antiinsulin serum, pancreatectomy, glucose infusion, β-cytotoxic agents, and viruses, is first considered. Attention is also paid to diabetogenic nutritional and hormonal factors, inhibitors of insulin release, and animal models of glycosuria. Second, both noninsulin-dependent spontaneous diabetes, such as that encountered in several rodent species, and insulin-dependent spontaneous diabetes, especially in NOD mice and BB rats, are briefly discussed. Last, the more recent use of gene targeting and transgenic techniques to explore the physiopathology of diabetes and the introduction of several insulin-secreting and other pancreatic endocrine cell lines in experimental diabetology are reviewed. © 2008 Humana Press Inc.