par D'Amico, D.J.;Caspers, Laure 
;Kenyon, K.R.;Hanninen, L.A.;Schrooyen, Marc ;Libert, Jacques
Référence American journal of ophthalmology, 100, page (264-75)
Publication Publié, 1985
;Kenyon, K.R.;Hanninen, L.A.;Schrooyen, Marc ;Libert, Jacques Référence American journal of ophthalmology, 100, page (264-75)
Publication Publié, 1985
Article révisé par les pairs
| Résumé : | We compared the toxicity of the aminoglycoside antibiotics (tobramycin, amikacin, netilmicin, and kanamycin) by ophthalmoscopy, light and electron microscopy, and electroretinography after intravitreal injection in rabbits in doses ranging from 100 to 3,000 μg. The earliest manifestations of toxicity were confined to the outer retina with each drug, with lamellar lysosomal inclusions in the retinal pigment epithelium as the earliest finding. However, the aminoglycosides displayed marked differences in the threshold dose required to produce toxic reactions, permitting the following ordering of toxicity: (most toxic) gentamicin > netilmicin = tobramycin > amikacin = kanamycin (least toxic). © 1985. |
