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Production of urea but absence of urea cycle in pancreatic islet cells

par Sener, Abdullah ;Blachier, François;Malaisse, Willy
Référence Medical science research, 16, page (483-484)
Publication Publié, 1988

Article révisé par les pairs

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Résumé :

Rat pancreatic islets produce large amounts of urea when exposed to L-arginine (10 mM). However, no urea cycle seems to be operative in islet cells. Indeed, islet homogenates fail to display ornithine transcarbamylase activity, and no [14C]-urea is produced by islets or RINm5F cells incubated with H14CO3- in the absence or presence of L-glutamine (10 mM). Moreover, no production of unlabelled urea could be detected in islets exposed to the latter amino acid.