par Lodewick, Julie ;Sampaio, Carla ;Boxus, Mathieu;Rinaldi, Anne-Sophie ;Coulonval, Katia ;Willems, Lucas ;Roger, Pierre P. ;Bex, Françoise
Référence Retrovirology, 10, page (75)
Publication Publié, 2013
Référence Retrovirology, 10, page (75)
Publication Publié, 2013
Article révisé par les pairs
Résumé : | Transformation by the Tax oncoprotein of the human T cell leukemia virus type 1 (HTLV-1) is governed by actions on cellular regulatory signals, including modulation of specific cellular gene expression via activation of signaling pathways, acceleration of cell cycle progression via stimulation of cyclin-dependent kinase activity leading to retinoblastoma protein (pRb) hyperphosphorylation and perturbation of survival signals. These actions control early steps in T cell transformation and development of Adult T cell leukemia (ATL), an aggressive malignancy of HTLV-1 infected T lymphocytes. Post-translational modifications of Tax by phosphorylation, ubiquitination, sumoylation and acetylation have been implicated in Tax-mediated activation of the NF-κB pathway, a key function associated with Tax transforming potential. |