Factors associated with surgical management following neoadjuvant therapy in patients with primary HER2-positive breast cancer: results from the NeoALTTO phase III trial.

Criscitiello, Carmen; Abdel Azim, Hatem Hamdy; Agbor-Tarh, Dominique; de Azambuja, Evandro; Piccart, P; Baselga, José; Eidtmann, Holger; Di Cosimo, Serena; Bradbury, Ian; Rubio, Isabel Teresa

doi:doi/10.1093/annonc/mdt129

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Factors associated with surgical management following neoadjuvant therapy in patients with primary HER2-positive breast cancer: results from the NeoALTTO phase III trial.

par Criscitiello, Carmen

;Abdel Azim, Hatem Hamdy

;Agbor-Tarh, Dominique ;de Azambuja, Evandro

;Piccart, P ;Baselga, José ;Eidtmann, Holger ;Di Cosimo, Serena ;Bradbury, Ian ;Rubio, Isabel Teresa
Référence Annals of oncology, 24, 8, page (1980-1985)
Publication Publié, 2013-08

Article révisé par les pairs

Résumé :

The NeoALTTO trial showed that dual HER2 blockade nearly doubles the rate of pathologic complete response (pCR) in patients with primary HER2-positive breast cancer. However, this did not translate into a higher rate of breast-conserving surgery (BCS).

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