Titre :
  • Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis.
Auteur : Flipo, Marion ; Willand, Nicolas ; Lecat-Guillet, Nathalie ; Hounsou, Candide ; Desroses, Matthieu ; Leroux, Florence ; Lens, Zoé ; Villeret, Vincent ; Wohlkonig, Alexandre ; Wintjens, René ; Christophe, Thierry ; Kyoung Jeon, Hee ; Locht, Camille ; Brodin, Priscille ; Baulard, Alain ; Déprez, Benoit
Informations sur la publication : Journal of medicinal chemistry, 55, 14, (page 6391-6402)
Statut de publication : Publié, 2012-07
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Acetamides -- chemical synthesis -- chemistry -- pharmacology
Animals
Antitubercular Agents -- pharmacology
Cell Line
Chemistry Techniques, Synthetic
Drug Discovery
Drug Synergism
Ethionamide -- pharmacology
High-Throughput Screening Assays
Ligands
Macrophages -- drug effects -- microbiology
Mice
Models, Molecular
Mycobacterium tuberculosis -- drug effects
Protein Conformation
Repressor Proteins -- antagonists & inhibitors -- chemistry
Note : Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
Langue :
  • Anglais
Identificateurs : urn:issn:0022-2623 
info:doi/10.1021/jm300377g
info:pmid/22738293