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Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis.

par Flipo, Marion;Willand, Nicolas;Lecat-Guillet, Nathalie;Hounsou, Candide;Desroses, Matthieu;Leroux, Florence;Lens, Zoé ;Villeret, Vincent ;Wohlkonig, Alexandre ;Wintjens, René ;Christophe, Thierry;Kyoung Jeon, Hee;Locht, Camille ;Brodin, Priscille;Baulard, Alain;Déprez, Benoit
Référence Journal of medicinal chemistry, 55, 14, page (6391-6402)
Publication Publié, 2012-07

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Titre:	Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis.
Auteur:	Flipo, Marion; Willand, Nicolas; Lecat-Guillet, Nathalie; Hounsou, Candide; Desroses, Matthieu; Leroux, Florence; Lens, Zoé; Villeret, Vincent; Wohlkonig, Alexandre; Wintjens, René; Christophe, Thierry; Kyoung Jeon, Hee; Locht, Camille; Brodin, Priscille; Baulard, Alain; Déprez, Benoit
Informations sur la publication:	Journal of medicinal chemistry, 55, 14, page (6391-6402)
Statut de publication:	Publié, 2012-07
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Acetamides -- chemical synthesis -- chemistry -- pharmacology
	Animals
	Antitubercular Agents -- pharmacology
	Cell Line
	Chemistry Techniques, Synthetic
	Drug Discovery
	Drug Synergism
	Ethionamide -- pharmacology
	High-Throughput Screening Assays
	Ligands
	Macrophages -- drug effects -- microbiology
	Mice
	Models, Molecular
	Mycobacterium tuberculosis -- drug effects
	Protein Conformation
	Repressor Proteins -- antagonists & inhibitors -- chemistry
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0022-2623
	info:doi/10.1021/jm300377g
	info:scp/84864261321
	info:pmid/22738293