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Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF.

par Anghel, Silvia I;Correa-Rocha, Rafael;Correa-Rochal, Rafael;Budinska, Eva;Boligan, Kayluz F;Boliganl, Kayluz F;Abraham, Shahnaz;Colombetti, Sara;Fontao, Lionel;Mariotti, A.;Rimoldi, Donata;Ghanem, Ghanem Elias ;Fisher, David E;Lévy, Frederic;Delorenzi, Mauro;Piguet, Vincent
Référence Pigment Cell & Melanoma Research, 25, 4, page (482-487)
Publication Publié, 2012-07

Article révisé par les pairs

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Résumé :

Understanding the molecular aberrations involved in the development and progression of metastatic melanoma (MM) is essential for a better diagnosis and targeted therapy. We identified breast cancer suppressor candidate-1 (BCSC-1) as a novel tumor suppressor in melanoma. BCSC-1 expression is decreased in human MM, and its ectopic expression in MM-derived cell lines blocks tumor formation in vivo and melanoma cell proliferation in vitro while increasing cell migration. We demonstrate that BCSC-1 binds to Sox10, which down regulates MITF, and results in a switch of melanoma cells from a proliferative to a migratory phenotype. In conclusion, we have identified BCSC-1 as a tumor suppressor in melanoma and as a novel regulator of the MITF pathway.