Titre :
  • AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments.
Auteur : Stamatopoulos, Basile ; Meuleman, Nathalie ; De Bruyn, Cécile ; Pieters, Karlien ; Mineur, Philippe ; Le Roy, Christine ; Saint-Georges, Stéphane ; Varin-Blank, Nadine ; Cymbalista, Florence ; Bron, Dominique ; Lagneaux, Laurence
Informations sur la publication : Haematologica, 97, 4, (page 608-615)
Statut de publication : Publié, 2012-04
Sujet CREF : Cancérologie
Mots-clés : Amd3100
Apoptosis
Chronic lymphocytic leukemia
Mesenchymal stromal cells
Microenvironment
Nurse-like cells
Mots-clés MeSH : Actins -- metabolism
Antibodies, Monoclonal -- immunology -- metabolism
Antineoplastic Agents -- pharmacology -- therapeutic use
Apoptosis -- drug effects
Cell Communication -- drug effects
Cell Movement -- drug effects
Cell Survival -- drug effects
Chemokine CXCL12 -- pharmacology
Coculture Techniques
Heterocyclic Compounds -- pharmacology -- therapeutic use
Humans
Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy -- metabolism
Leukocytes, Mononuclear -- drug effects -- metabolism
Mesenchymal Stromal Cells -- drug effects -- metabolism
Protein Binding -- drug effects -- immunology
Protein Multimerization -- drug effects
Receptors, CXCR4 -- antagonists & inhibitors -- immunology -- metabolism
Tumor Microenvironment -- drug effects
Note : Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
Langue :
  • Anglais
Identificateurs : urn:issn:0390-6078 
info:doi/10.3324/haematol.2011.052779
info:pii/haematol.2011.052779
info:pmid/22058221
info:pmcid/PMC3347654