Titre :
  • A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis.
Auteur : Rice, Todd W ; Wheeler, Arthur ; Bernard, Gordon ; Vincent, Jean Louis ; Angus, Derek ; Aikawa, Naoki ; Demeyer, Ignace ; Sainati, Stephen ; Amlot, Nicholas ; Cao, Charlie ; Ii, Masayuki ; Matsuda, Hideyasu ; Mouri, Kouji ; Cohen, Jonathan
Informations sur la publication : Critical care medicine, 38, 8, (page 1685-1694)
Statut de publication : Publié, 2010-08
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : cytokines
interleukin-6
mortality
severe sepsis
TAK-242
Toll-like receptor-4
Toll-like receptors
Mots-clés MeSH : Adult
Aged
Cytokines -- drug effects -- metabolism
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Female
Follow-Up Studies
Hospital Mortality -- trends
Humans
Infusions, Intravenous
Male
Middle Aged
Multiple Organ Failure -- prevention & control
Probability
Pulse Therapy, Drug
Reference Values
Risk Assessment
Sepsis -- diagnosis -- drug therapy -- mortality
Sulfonamides -- administration & dosage -- adverse effects
Survival Analysis
Treatment Outcome
Note : Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
Langue :
  • Anglais
Identificateurs : urn:issn:0090-3493 
info:doi/10.1097/CCM.0b013e3181e7c5c9
info:pii/S0090349310604130
info:pmid/20562702