Titre :
  • Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter.
Auteur : Guignabert, Christophe ; Tu, Ly ; Izikki, Mohamed ; Dewachter, Laurence ; Zadigue, Patricia ; Humbert, Marc ; Adnot, Serge ; Fadel, Elie ; Eddahibi, Saadia
Informations sur la publication : The FASEB journal, 23, 12, (page 4135-4147)
Statut de publication : Publié, 2009-12
Sujet CREF : Physiologie générale [biophysique]
Mots-clés MeSH : Animals
Apoptosis -- drug effects
Cell Proliferation -- drug effects
Cells, Cultured
Dichloroacetic Acid -- therapeutic use
Female
Fluoxetine -- pharmacology
Gene Expression Regulation -- physiology
Hypertension, Pulmonary -- drug therapy
Kv1.5 Potassium Channel -- genetics -- metabolism
Male
Mice
Microfilament Proteins -- genetics -- metabolism
Muscle Proteins -- genetics -- metabolism
Muscle, Smooth, Vascular -- cytology
Myocytes, Smooth Muscle -- drug effects -- metabolism
NFATC Transcription Factors -- genetics -- metabolism
Pulmonary Artery
Serotonin Plasma Membrane Transport Proteins -- genetics -- metabolism
Serotonin Uptake Inhibitors -- pharmacology
Note : Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0892-6638 
info:doi/10.1096/fj.09-131664
info:pii/fj.09-131664
info:pmid/19679640