par Carpentier, Rodolphe;Suñer, Regina Español;van Hul, Noémi;Kopp, Janel L;Beaudry, Jean-Bernard;Cordi, Sabine;Antoniou, Aline 
;Raynaud, Peggy;Lepreux, Sébastien;Jacquemin, Patrick;Leclercq, Isabelle A;Sander, Maike;Lemaigre, Frédéric P
Référence Gastroenterology, 141, 4, page (1432-8, 1438.e1-4)
Publication Publié, 2011-10
;Raynaud, Peggy;Lepreux, Sébastien;Jacquemin, Patrick;Leclercq, Isabelle A;Sander, Maike;Lemaigre, Frédéric PRéférence Gastroenterology, 141, 4, page (1432-8, 1438.e1-4)
Publication Publié, 2011-10
Article révisé par les pairs
| Résumé : | BACKGROUND& AIMS: Embryonic biliary precursor cells form a periportal sheet called the ductal plate, which is progressively remodeled to generate intrahepatic bile ducts. A limited number of ductal plate cells participate in duct formation; those not involved in duct development are believed to involute by apoptosis. Moreover, cells that express the SRY-related HMG box transcription factor 9 (SOX9), which include the embryonic ductal plate cells, were proposed to continuously supply the liver with hepatic cells. We investigated the role of the ductal plate in hepatic morphogenesis. |
