Titre :
  • Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.
Auteur : Tanioka, Toshihiro ; Tamura, Yoshiaki ; Fukaya, Makiko ; Shinozaki, Shohei ; Mao, Ji ; Kim, Minhye ; Shimizu, Nobuyuki ; Kitamura, Tadahiro ; Kaneki, Masao
Informations sur la publication : The Journal of biological chemistry, 286, 33, (page 29388-29396)
Statut de publication : Publié, 2011-08
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Acetylcysteine -- analogs & derivatives -- pharmacology
Animals
Anthracenes -- pharmacology
Cell Line, Tumor
Cysteine Proteinase Inhibitors -- pharmacology
Enzyme Activation -- drug effects -- physiology
Gene Expression Regulation -- drug effects -- physiology
Glycogen Synthase Kinase 3 -- antagonists & inhibitors -- genetics -- metabolism
Humans
Insulin Receptor Substrate Proteins -- biosynthesis -- genetics
Insulin-Secreting Cells -- cytology -- metabolism
Interferon-gamma -- genetics -- metabolism
Interleukin-1beta -- genetics -- metabolism
JNK Mitogen-Activated Protein Kinases -- antagonists & inhibitors -- genetics -- metabolism
Leupeptins -- pharmacology
Mice
Nitric Oxide Donors -- pharmacology
Nitric Oxide Synthase Type II -- genetics -- metabolism
Proteasome Endopeptidase Complex -- genetics -- metabolism
Proteasome Inhibitors
Rats
Note : Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0021-9258 
info:doi/10.1074/jbc.M110.192732
info:pii/M110.192732
info:pmid/21700708
info:pmcid/PMC3190744