Titre :
  • Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to beta-cell apoptosis.
Auteur : Allagnat, Florent ; Andrade Da Cunha, Daniel ; Moore, F ; Vanderwinden, J M ; Eizirik, Decio L. ; Cardozo, Alessandra K
Informations sur la publication : Cell death and differentiation, 18, 2, (page 328-337)
Statut de publication : Publié, 2011
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : apoptosis
diabetes
eIF2a
JNK
Mcl-1
pancreatic β-cells
Mots-clés MeSH : Animals
Apoptosis
Caspase 3 -- metabolism
Cell Line, Tumor
Cytochromes c -- metabolism
Cytokines -- pharmacology
Down-Regulation
Endoplasmic Reticulum -- metabolism
Insulin-Secreting Cells -- cytology -- metabolism
Palmitates -- pharmacology
Proto-Oncogene Proteins c-bcl-2 -- genetics -- metabolism
RNA Interference
RNA, Small Interfering -- metabolism
Rats
Thapsigargin -- pharmacology
bcl-2-Associated X Protein -- metabolism
bcl-X Protein -- metabolism
Note : Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
Langue :
  • Anglais
Identificateurs : urn:issn:1350-9047 
info:doi/10.1038/cdd.2010.105
info:pii/cdd2010105
info:pmid/20798690
info:pmcid/PMC3131897