par Dobbie, J W;Hind, C;Meijers, P;Bodart, M.;Tasiaux, Nicole 
;Perret, Jason ;Anderson, J D
Référence British journal of rheumatology, 34, 1, page (13-23)
Publication Publié, 1995-01
;Perret, Jason ;Anderson, J DRéférence British journal of rheumatology, 34, 1, page (13-23)
Publication Publié, 1995-01
Article révisé par les pairs
| Résumé : | The intra- and extracellular distribution and relative density of lamellar bodies (LBs) were determined by electron microscopy in synovial biopsies from 20 non-rheumatoid arthritis (RA) patients. LBs were found on the synovial surface, in intimal cells, throughout intimal matrix, in blood vessel walls, in endothelial cytoplasm and within vascular lumena. Lamellar profiles were observed in type B synoviocytes within rough endoplasmic reticulum (RER), in association with the Golgi apparatus, and embedded in electron dense matrix (projection cores) in multivesicular bodies. Exocytotic release of mature LBs into intimal matrix was observed. In type A synoviocytes the outer lamellae of LBs were frequently found in contiguity with the limiting membrane of lysosomes. An in vitro investigation of the ultrastructural features of LB formation in cultured type B synoviocytes (from 3 non-RA patients) gave results similar to those obtained in biopsies. These studies provide ultrastructural evidence of synoviocyte activity in secreting and degrading phospholipid lubricant in a sophisticated system whose function and pathological derangements are largely unknown. |
