par von Hahn, Thomas;Schiene-Fischer, Cordelia;Van, Nguyen Dinh;Pfaender, Stephanie;Karavul, Behya;Steinmann, Eike;Potthoff, Andrej;Strassburg, Christian;Hamdi, Nabila;Abdelaziz, Ahmed Ihab;Sarrazin, Christoph;Müller, Tobias;Berg, Thomas;Trepo, Eric ;Wedemeyer, Heiner;Manns, Michael P;Pietschmann, Thomas;Ciesek, Sandra
Référence Gastroenterology, 143, 2, page (439-47.e1)
Publication Publié, 2012-08
Référence Gastroenterology, 143, 2, page (439-47.e1)
Publication Publié, 2012-08
Article révisé par les pairs
Résumé : | Hepatitis C virus (HCV) uses several host factors to infect and replicate in human hepatocytes. Cyclophilin A (CypA) is required for viral replication, and CypA inhibitors are in development. We investigated the effects of nonsynonymous single nucleotide polymorphisms (SNPs) in the region of peptidyl-prolyl isomerase A (PPIA) that encodes CypA on HCV infection and replication of human hepatocytes. |