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Repair of the in vitro HIV-1-induced immunosuppression and blockade of the generation of functional suppressive CD8 cells by anti-alpha interferon and anti-Tat antibodies

par Lachgar, Abderrahim;Bernard, Jacky;Bizzini, Bernard;Astgen, A.;Le Coq, H.;Fouchard, Michéle;Chams, Vida;Feldman, M;Burny, Arsène ;Zagury, Jean-François
Référence Biomedicine & pharmacotherapy, 50, 1, page (13-18)
Publication Publié, 1996

Article révisé par les pairs

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Résumé :

The acute human immunodeficiency virus type 1 (HIV-1) infection of activated peripheral blood mononuclear cells (PBMCs) from normal donors results in inhibition of cell proliferation and generation of functional suppressive T cells. Cultured HIV-1 infected PBMCs but not uninfected PBMCs, following irradiation, can inhibit the proliferation of antigen-activated autologous T cells in a dose-dependent way. CD8' cell subpopulation is responsible for this inhibition. The presence of anti-alpha interferon (IFNα) and anti-Tat antibodies in the culture medium counteracts the HIV-1-induced immunosuppression and prevents the generation of suppressive T cells by these PBMCs. The reported data should have major implications for strategies of AIDS treatment which, in association with antiviral drugs, aim at targetting immune disorders.