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Dexamethasone treatment of amiodarone-induced thyrotoxicosis (AIT) with or without persistent administration of the drug.

par Bonnyns, Marc ;Sterling, I.;Renard, Marc ;Bernard, Roland ;Demaret, Betty;Bourdoux, Pierre
Référence Acta cardiologica, 44, 3, page (235-243)
Publication Publié, 1989

Article révisé par les pairs

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Résumé :

Treatment of amiodarone-induced thyrotoxicosis (AIT) with thionamide, lithium or radioactive iodine is ineffective. This particular form of hyperthyroidism is long-lasting because of the slow elimination of amiodarone. Therefore, an alternative therapy is necessary, especially for patients who need to continue permanent administration of the drug. We report 2 cases of AIT: in one case, amiodarone was interrupted; in the other case, amiodarone was continued because of recurrent ventricular tachycardia resistant to classical antiarrhythmic drugs. Both patients were successfully treated with propylthiouracil (PTU) and dexamethasone (DXT).