par Khelili, Smail;Kihal, Nadjib;Yekhlef, Mohamed;de Tullio, Pascal;Lebrun, Philippe ;Pirotte, Bernard
Référence European journal of medicinal chemistry, 54, page (873-878)
Publication Publié, 2012-05
Référence European journal of medicinal chemistry, 54, page (873-878)
Publication Publié, 2012-05
Article révisé par les pairs
Résumé : | N-(2,2-Dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides were prepared and evaluated on rat uterus, rat aortic rings and rat pancreatic β-cells. Pharmacological studies conducted on rat uterus indicated that several of these original hybrid compounds displayed a strong myorelaxant activity. The most active compounds hold a bromine atom at the 6-position of the dihydrobenzopyran ring. Moreover, the compounds failed to display a marked inhibitory effect on insulin secretion and vascular myogenic activity. These features suggest that the 6-bromo compounds could be relatively selective towards the uterine smooth muscle. |