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Total Synthesis of Chaetominine

par Toumi, Mathieu;Couty, François;Marrot, Jérôme;Evano, Gwilherm
Référence Organic letters, 10, 21, page (5027-5030)
Publication Publié, 2008

Article révisé par les pairs

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Résumé :

An efficient, asymmetric synthesis of the cytotoxic natural product chaetominine was achieved in 14 steps. The strategy employs a copper(I)- mediated cyclization reaction as a key step to install the abc-tricyclic ring system, which was further elaborated by diastereoselective oxidation and reduction reaction