par Magueur, G.;Legros, J.;Meyer, Franck ;Ourevitch, Michèle;Crousse, B.;Bonnet-Delpon, D.
Référence European Journal of Organic Chemistry, 2005, 7, page (1258-1265)
Publication Publié, 2005-04
Référence European Journal of Organic Chemistry, 2005, 7, page (1258-1265)
Publication Publié, 2005-04
Article révisé par les pairs
Résumé : | A straightforward route to trifluoromethyl analogs of piperidines is described. These syntheses involve a Barbier-type allylation reaction of trifluoroacetaldimines, followed by N-allylation (one-pot), and ring-closing metathesis. An efficient asymmetric version is also reported (>98 % de). Functionalized heterobicyclic compounds can also be obtained by a Pauson–Khand reaction. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005) |