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Constant estrogen, intermittent progestogen vs. continuous combined hormone replacement therapy: Tolerability and effect on vasomotor symptoms

par Rozenberg, Serge ;Caubel, Patrick ;Lim, Peter
Référence International journal of gynaecology and obstetrics, 72, 3, page (235-243)
Publication Publié, 2001

Article révisé par les pairs

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Résumé :

Objective: To compare the efficacy and tolerability of a novel oral constant estrogen plus intermittent progestogen hormone replacement therapy (HRT) regimen to a continuous combined HRT regimen in postmenopausal women. Methods: Subjects were randomly assigned to receive treatment with either constant 17β-estradiol (E2), 1 mg, plus intermittent norgestimate (NGM) 90 μg (3 days off, 3 days on) (n=221) or E2 2 mg/norethisterone acetate (NETA) 1 mg (n=217) for 1 year. Treatments were evaluated based on the incidence of hot flushes and uterine bleeding. Results: Both regimens had similar bleeding profiles and provided comparable vasomotor symptom relief. However, breast discomfort and edema were experienced by twice as many subjects who received E2/NETA. Conclusions: The constant E2/intermittent NGM regimen was well tolerated and possesses similar efficacy compared with a continuous combined E2/NETA regimen and may be considered whenever HRT without withdrawal bleeding is deemed appropriate. Copyright © 2001 International Federation of Gynecology and Obstetrics. All rights reserved.