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Clinical usefulness of EGFR gene copy number as a predictive marker in colorectal cancer patients treated with cetuximab: a fluorescent in situ hybridization study.

par Personeni, Nicola;Fieuws, Steffen;Piessevaux, Hubert;De Hertogh, Gert;De Schutter, Jef;Biesmans, Bart;De Roock, Wendy;Capoen, An;Debiec-Rychter, Maria;Van Laethem, Jean-Luc ;Peeters, Marc;Humblet, Yves;Van Cutsem, Eric;Tejpar, Sabine
Référence Clinical cancer research, 14, 18, page (5869-5876)
Publication Publié, 2008-09

Article révisé par les pairs

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Résumé :

To evaluate the usefulness and the pitfalls inherent to the assessment of the epidermal growth factor receptor (EGFR) gene copy number (GCN) by fluorescence in situ hybridization (FISH) for outcome prediction to cetuximab in metastatic colorectal cancer. The value of testing KRAS mutation status, in addition to EGFR GCN, was also explored.