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Phase III trial comparing protracted intravenous fluorouracil infusion alone or with yttrium-90 resin microspheres radioembolization for liver-limited metastatic colorectal cancer refractory to standard chemotherapy.

par Hendlisz, Alain ;Van Den Eynde, Marc;Peeters, Marc;Maleux, G;Lambert, Bieke;Vannoote, Jaarke;De Keukeleire, Katrien;Verslype, Chris;Defreyne, L;Van Cutsem, Eric;Delatte, Philippe ;Delaunoit, Thierry ;Personeni, Nicola;Paesmans, Marianne ;Van Laethem, Jean-Luc ;Flamen, Patrick
Référence Journal of clinical oncology, 28, 23, page (3687-3694)
Publication Publié, 2010-08

Article révisé par les pairs

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Résumé :

Liver dissemination is a major cause of mortality among patients with advanced colorectal cancer. Hepatic intra-arterial injection of the beta-emitting isotope yttrium-90 ((90)Y) bound to resin microspheres (radioembolization) delivers therapeutic radiation doses to liver metastases with minimal damage to adjacent tissues.