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Enteral nutrition with or without N-acetylcysteine in the treatment of severe acute alcoholic hepatitis: a randomized multicenter controlled trial.

par Moreno, Christophe ;Langlet, Philippe ;Hittelet, Axel-Benoit ;Lasser, Luc ;Degré, Delphine ;Evrard, Sylvie ;Colle, Isabelle;Lemmers, Arnaud ;Devière, Jacques ;Le Moine, Olivier
Référence Journal of hepatology, 53, 6, page (1117-1122)
Publication Publié, 2010-12

Article révisé par les pairs

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Résumé :

Severe acute alcoholic hepatitis is associated with a high mortality rate. Oxidative stress is involved in the pathogenesis of acute alcoholic hepatitis. Previous findings had also suggested that enteral nutritional support might increase survival in patients with severe acute alcoholic hepatitis. Therefore, the aim of the present study was to evaluate the efficacy of N-acetylcysteine in combination with adequate nutritional support in patients with severe acute alcoholic hepatitis.