Titre :
  • Oleate-induced beta cell dysfunction and apoptosis: a proteomic approach to glucolipotoxicity by an unsaturated fatty acid.
Auteur : Maris, Michael ; Waelkens, Etienne ; Cnop, Miriam ; D'Hertog, Wannes ; Andrade Da Cunha, Daniel ; Korf, Hannelie ; Koike, T. ; Overbergh, Lutgart ; Mathieu, Chantal
Informations sur la publication : Journal of proteome research, 10, 8, (page 3372-3385)
Statut de publication : Publié, 2011
Sujet CREF : Médecine clinique [biologie clinique]
Sciences bio-médicales et agricoles
Mots-clés : beta cells
lipotoxicity
oleate
proteomics
type 2 diabetes
Mots-clés MeSH : Adenosine Triphosphate -- metabolism
Animals
Apoptosis -- drug effects
Base Sequence
Cell Line
DNA Primers
Electrophoresis, Gel, Two-Dimensional
Fatty Acids, Unsaturated -- pharmacology
Glucose -- toxicity
Insulin -- secretion
Islets of Langerhans -- drug effects -- metabolism -- physiopathology -- secretion
Lipids -- toxicity
Oleic Acid -- pharmacology
Polymerase Chain Reaction
Proteomics
Rats
Reactive Oxygen Species -- metabolism
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Tandem Mass Spectrometry
Note : Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
Langue :
  • Anglais
Identificateurs : urn:issn:1535-3893 
info:doi/10.1021/pr101290n
info:pmid/21707097