par Lamoral-Theys, Delphine ;Fattorusso, Ernesto;Mangoni, Alfonso;Perinu, Cristina;Kiss, Robert ;Costantino, Valeria
Référence Journal of natural products, 74, 10, page (2299-2303)
Publication Publié, 2011-10
Référence Journal of natural products, 74, 10, page (2299-2303)
Publication Publié, 2011-10
Article révisé par les pairs
Résumé : | One new (1) and three known (2-4) isonitrile diterpenes, isolated from the Caribbean sponge Pseudoaxinella flava, were assayed in human cancer cell lines in vitro using an MTT colorimetric assay and quantitative videomicroscopy. Compounds 1-4 displayed activity for human PC3 prostate apoptosis-sensitive cancer cell lines. Compounds 3 and 4 demonstrated similar growth inhibitory effects for three apoptosis-sensitive and three apoptosis-resistant cancer cell lines. Quantitative videomicroscopy analysis revealed that compounds 1 and 2 exerted their activity through cytotoxic effects, and compounds 3 and 4 through cytostatic effects. These results identify marine diterpene isonitriles as potential lead compounds for anticancer drug discovery. |