par Verset, Laurine 
;Arvanitakis, Marianna ;Loi, Patrizia ;Closset, Jean ;Delhaye, Myriam ;Remmelink, Myriam ;Demetter, Pieter
Référence World journal of gastrointestinal oncology, 3, 10, page (144-147)
Publication Publié, 2011-10
;Arvanitakis, Marianna ;Loi, Patrizia ;Closset, Jean ;Delhaye, Myriam ;Remmelink, Myriam ;Demetter, Pieter Référence World journal of gastrointestinal oncology, 3, 10, page (144-147)
Publication Publié, 2011-10
Article révisé par les pairs
| Résumé : | Thyroid transcription factor 1 (TTF-1) plays a key role in morphogenesis of the lungs and is expressed in up to 90% of pulmonary small cell carcinomas. This explains why this marker is frequently used in the search for the primary origin of metastatic endocrine tumours. Here we report on a TTF-1 expressing mixed endocrine-exocrine carcinoma of the common bile duct in a patient with pulmonary nodules that did not appear to be neoplastic. TTF-1 positivity in pulmonary and extrapulmonary neuroendocrine tumours is reviewed, and we conclude that TTF-1 expression in neuroendocrine tumours of the small-cell type are not uncommon at extrapulmonary locations. Therefore, immunohistochemistry for TTF-1 in such tumours should be interpreted with caution. |
