par Coste, Alexis;Couty, François;Evano, Gwilherm 
;Toumi, Mathieu;Wright, Karen;Razafimahaléo, Vanessa;Marrot, Jérôme
Référence Organic letters, 10, 17, page (3841-3844)
Publication Publié, 2008
;Toumi, Mathieu;Wright, Karen;Razafimahaléo, Vanessa;Marrot, JérômeRéférence Organic letters, 10, 17, page (3841-3844)
Publication Publié, 2008
Article révisé par les pairs
| Résumé : | Pyrroloindoles are a key structural motif found in a wide number of biologically active alkaloids. Intramolecular copper-catalyzed coupling of readily accessible 2-iodo-tryptophan derivatives occurs in excellent yield, affording a wide range of polysubstituted, enantioenriched tetrahydropyrrolo[2,3-b]indoles. Diketopiperazines are also suitable substrates for this cyclization reaction, which affords a straightforward entry to tetra- to hepta-polycyclic systems. |
